Programs that are designed to support people who use drugs when they are alone and are consequently at higher risk of overdose, by connecting them to emergency responders automatically if they become unresponsive. Included are overdose prevention applications ("apps") where users inform their location and when they're about to use substances; depending on the technology, the app may sound an alarm that the user must stop to indicate that they're safe or may use a sonar to monitor the person's breathing and detect a potential overdose. Also included are overdose prevention hotlines where users are connected with peers with lived experience who provide them with support and can send them help if something goes wrong.

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Programs that help prevent the transmission of HIV/AIDS, hepatitis B and C, and other blood-borne infectious diseases by providing new, sterile and single use equipment and biohazard containers for safe disposal, in order to reduce the spread of these diseases. Supplies provided may vary per program and can include safe injection supplies, safe inhalation supplies, drug testing, and antidotes to reverse an overdose from opioids. Also included are supplies for safe hormone injection for trans, gender diverse, and two-spirited individuals who face unique barriers and inequitable access to gender-affirming health care services. The distribution of supplies is part of a comprehensive public health disease prevention strategy with the goal to reduce re-using and sharing drug use equipment.

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